Mixed-Mode Cleanup Technique for Drug in Meat Products

October 1, 2008

Researchers from the Technical University of Denmark and (Lyngby, Denmark) and the Danish Meat Research Institute (Roskilde, Denmark) used a mixed-mode reversed phase?anion exchange cleanup method followed by LC-MS with electrospray ionization time-of-flight detection to analyze mycophenolic acid in dry-cured ham, fermented sausage, and liver pate.

Researchers from the Technical University of Denmark and (Lyngby, Denmark) and the Danish Meat Research Institute (Roskilde, Denmark) used a mixed-mode reversed phase–anion exchange cleanup method followed by LC-MS with electrospray ionization time-of-flight detection to analyze mycophenolic acid in dry-cured ham, fermented sausage, and liver pate. The mycophenolic acid, a compound used an immunosuppressant in organ transplantation, was first extracted from the meat with a bicarbonate–acetonitrile solution.