Multidimensional Liquid Chromatography in Proteomic Studies

Analytical laboratories are undergoing a fundamental transformation. In the face of increasing sample volumes, growing regulatory requirements, and the rising demand for faster, more precise, and cost-efficient analysis, optimizing laboratory processes is becoming a central focus. Automation technologies offer promising solutions in this regard. Recently, they have evolved from isolated solutions to comprehensive systems that permeate nearly all areas of laboratory practice. This development not only opens up new opportunities in terms of efficiency, data quality, and scalability but also brings technical, organizational, and personnel challenges. To successfully address these, strategic approaches are needed that consider both the technological and human dimensions of the transformation.

LCGC International’s Rising Star of Separation Science Winner for the LC Category, Bram Huygens from the Vrije Universiteit Brussel in Brussels, Belgium, recaps the work he presented for his award and his current research focus.

Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.

Brett Paull from the University of Tasmania, Tasmania and his team describe the latest development in portable LC instruments and their experience of taking portable systems out to the field.

High-performance liquid chromatography (HPLC) was recently used to detect acylated impurities in artificial hormones meant to treat prostate cancer symptoms.

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