NuGEN (San Carlos, California) and the Hamilton Company (Reno, Nevada) have assembled an automated, total target preparation system for high-throughput processing of clinical samples for global gene expression analysis. The system, which consists of NuGEN’s Ovation Systems RNA amplification and labeling products and Hamilton’s Microlab Starlet benchtop liquid handling system, was engineered to increase throughput and improve workflow for small RNA samples used in clinical signature and biomarker discovery.