Scientists from Lorillard Tobacco Company (Greensboro, North Carolina) developed an improved method for analyzing polycyclic aromatic hydrocarbons (PAHs) in mainstream tobacco smoke. They used two types of solid-phase extraction (SPE) media to remove matrix interferences and performed the analysis with gas chromatography–mass spectrometry (GC–MS). They achieved a reduction in analysis run time as well as an increase in accuracy. The researchers also used a chilled impinger to trap semivolatile PAHs.