Per- and Polyfluoroalkyl Substances (PFAS), a family of more than 4,700 chemical molecules, are known for their non-stick and waterproof properties. These versatile compounds find their application in a variety of industries, including cosmetics, textiles, and automobiles. PFAS exhibit remarkable resistance to degradation, which has led to their pervasive distribution in the environment and consequent human exposure. The effects of such exposure are far-reaching, including adverse effects on fertility, developmental abnormalities, cholesterol levels, immune function, and an increased risk of certain cancers. In addition to their toxicological effects, PFAS have become a global concern as regulators and researchers strive to understand the extent of their impact and develop effective methods for detection and mitigation.
This collection of articles brings together research on the contamination and effects of PFAS in air, soil, and water, shedding light on the complex challenges posed by these persistent substances in our environment. Overall, this collection of articles seeks to advance researchers' knowledge of the dynamics, effects, and detection of PFAS.
In this fifth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses how to overcome challenges with reversed-phase chromatography in drug analysis.
This week on Chromatography Online, leading experts shared practical insights with LCGC International on sustainable affinity methods, siRNA impurity profiling, nontarget screening, peptide tech transfer, and AI in separation science.
Anneli Kruve reports that toxicity predictions from MS2-derived molecular fingerprints outperform spectral-similarity methods in nontarget screening of food.
In this fourth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why buffers are most often used in Mobile Phase A in high-pressure liquid chromatography of pharmaceuticals.
