Practical Aspects of Mucopolysaccharidoses Screening with Thin-Layer Chromatography

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LCGC North America

LCGC North America, LCGC North America-04-01-2001, Volume 19, Issue 4

Scored layers, sequential development, modifications of the development chamber, and a careful choice of standards produce better reliability in thin-layer chromatography analysis of urine for the diagnosis of mucopolysaccharidoses. In equivocal cases, repeating the procedure and varying the solvents will improve results.