prominence TOX.I.S. (HPLC/PDA for identification of drugs in human urine)

LCGC Europe eNews

The Shimadzu prominence TOX.I.S. system is based on well-established LC hardware modules. Their patented flow line design and column switching procedure enable pre-treatment of urine samples with a cleaning step, rinsing to remove proteins and other urine components, and transfer of the sample onto the analytical columns for separation.

Acute poisoning, drug abuse or use of illegal substances - toxicological analysis of body fluids is a major task, for criminal prosecution, in emergencies or in sport. Such analyses require a universal sample pre-treatment and identification method, and need to be automated for speed and simplicity.

The Shimadzu prominence TOX.I.S. system is based on well-established LC hardware modules. Their patented flow line design and column switching procedure enable pre-treatment of urine samples with a cleaning step, rinsing to remove proteins and other urine components, and transfer of the sample onto the analytical columns for separation.

Selection valves for the analytical columns make it possible to use the system also for the analysis of blood/serum samples after a separate liquid/liquid extraction procedure, or the determination of alcohol abuse marker (% CDT).

Detection and identification are carried out with photodiode-array detector and library search matches with UV spectra and relative retention time.

For the system application, kits are available from RECIPE (www.recipe.de).

For further information visit our website at www.shimadzu.eu