Quantitative Analysis of Drugs of Abuse in Urine Using UHPLC Coupled to A TOF Mass Spectrometer

Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.

Michael Dong recently discussed sample preparation (SP) techniques for small-molecule drug substances and solid dosage forms.

During a recent LCGC International peer exchange discussion on nitrosamine analysis, our professional panelists discussed the complex issues surrounding the processes for detecting nitrosamines.

LCGC International spoke with Daniel Meston and Dwight Stoll from Gustavus Adolphus College in St. Peter, Minnesota, USA, about a project they worked on with Todd Maloney from Eli Lilly in Indianapolis, Indiana, USA, to investigate the optimal performance conditions of antisense oligonucleotides (ASOs) when using hydrophilic interaction liquid chromatography (HILIC).

This article discusses several practical examples using bioinert columns, demonstrating their ability to deliver reliable, high-resolution results with precision and reproducibility.

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.