Researchers conducting clinical research trials of patients with bladder cancer have discovered a non-invasive way to detect the cancer by using HPLC/MS.
Researchers conducting clinical research trials of patients with bladder cancer have discovered a non-invasive way to detect the cancer by using HPLC/MS. In the current study using sophisticated statistical methods the researchers were able to identify and characterize urine metabolite profiles obtained from patients with bladder cancer over controls. Identification and quantitative measurements of all the metabolites expressed in urine, serum, plasma, and tissue are essential for the study of biological processes in normal and disease states. High performance liquid chromatography was used to resolve the metabolites in urine that were detected by mass spectrometry according to their mass-to-charge ratio. Mass spectrometry was selected for this study because of its sensitivity.
The next step in their research will be the identification of key metabolites that are typical to patients with superficial bladder cancer. This may help to improve and simplify diagnosis of patients with bladder tumors. Furtherer more it will help to better understand their role in the pathophysiology of the disease and possible as a future target for therapeutic intervention.
Best of the Week: What’s New in MS, 2024 Young Chemist Award Winner
March 22nd 2024This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!
Inside the Laboratory: The Schug Group at the University of Texas at Arlington
March 22nd 2024In this edition of “Inside the Laboratory,” Kevin Schug, PhD, a full professor of chemistry at the University of Texas at Arlington, discusses his laboratory’s group work in environmental monitoring around water and soil quality near oil and gas extraction, using techniques such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and coupling these techniques with mass spectrometry (MS).
Cloruson and Related Substances Studied Using Original Ion-Pair UHPLC Method
March 19th 2024In a recent study out of Boehringer Ingelheim Animal Health USA Inc. in North Brunswick, New Jersey, scientists investigated cloruson and its related substances using an original ion-paired reversed phase ultraperformance liquid chromatography (IP-UHPLC) method.