A research group from NRL Marine Biotoxins, Federal Institute for Risk Assessment (Berlin, Germany) developed a solid-phase extraction (SPE) method for the enrichment and clean-up of lipophilic marine biotoxins from various species of bivalve molluscs and processed shellfish products. They tested the method with a concentration range corresponding to that of current European Union regulatory limits. The compounds analyzed in the study were okadaic acid, pectenotoxin2, azaspiracid1, and yessotoxin.