In this final part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor presents a case study of a high-pH separation.
|Articles|March 1, 2021
Supplementary Information: Non-aqueous Ion-Exchange Chromatography Using High Acid‑base Concentration: A Strategy for Purifying Non-crystalline Pharmaceutical Intermediates
This information is supplementary to the article “Non-aqueous Ion-Exchange Chromatography Using High Acid‑base Concentration: A Strategy for Purifying Non-crystalline Pharmaceutical Intermediates” that was published in the March 2021 issue of LCGC Europe.
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The following document below includes the following supplementary information for the peer-reviewed article “Non-aqueous Ion-Exchange Chromatography Using High Acid‑base Concentration: A Strategy for Purifying Non-crystalline Pharmaceutical Intermediates” that was published in the March 2021 issue of LCGC Europe:
- The HPLC conditions
- Additional information on calculations, including the milligram to multigram scale calculations and the multigram to multikilogram calculations
- Table A: Physical and chemical properties of the selected cation exchange resin
- Table B: Experimental details and scaling
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