Tips & Tricks: GPC/SEC Copolymer Analysis in GPC/SEC 2: Polymer Liquid Adsorption Chromatography (LAC)

Copolmyer analysis is challenging due to the effect that at least two distributions can be present simultaneously, the molar mass distribution (MMD) and the chemical composition distribution (CCD).

While there are molar mass sensitive detectors for the determination of the MMD of homopolymers, the applicability of these detectors for copolymers suffers from potential co-elution in GPC/SEC and (in case of light scattering) from the dependence of the dn/dc on composition. In addition, these detectors do not provide any insight into the CCD.

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