Tuesday Afternoon Session: Pharmaceutical Analysis
The session titled "Pharmaceutical Analysis" will be chaired by Wolfgang Goetzinger of Amgen Inc. (Cambridge, Massachusetts) and Robert Plumb of Imperial College (London, UK) on Tuesday afternoon in Ballroom A.
The session titled “Pharmaceutical Analysis” will be chaired by Wolfgang Goetzinger of Amgen Inc. (Cambridge, Massachusetts) and Robert Plumb of Imperial College (London, UK) on Tuesday afternoon in Ballroom A.
Klaus Albert of the Institute of Organic Chemistry will start off this session with a presentation titled "Structure Elucidation of Bioactive Compounds Employing Modern Analytical Hyphenated Techniques." The study of bioactive compounds is very popular right now for the development of of pharmaceuticals by industry and academia. This presentation will surely touch upon a lot of the important factors involved with bioactive compounds.
The second presentation in this session will be given by Csaba Horvath Award nominee Volker Neu of the University of Salzburg (Salzburg, Austria) and is titled "High-Speed Liquid Chromatography Hyphenated to High-Resolution Mass Spectrometry in Pharmaceutical Quality Control." Neu's discussion will center around another important issue for the pharmaceutical industry- quality control. This is an area of pharmaceuticals that is always looking for room to grow and improve upon itself.
The third presentation will focus on the detection of impurities in drug formulations. Rudy Sneyers of Johnson and Johnson (Beerse, Belgium) will preesnt "'Safety Net' — Systematic Application of Orthogonal Methods for Automated Detection of New Impurity Compounds in Drug Formulations."
The final presentation in this session will be given by Christopher J. Welch of Merck & Co., Inc. (Rahway, New Jersey) and is titled "New HPLC Technologies in Support of Pharmaceutical Discovery and Development." A fitting end to this session, this topic will touch upon discovery and development in the pharmaceutical industry using HPLC.
Modern HPLC Strategies: Improving Retention and Peak Shape for Basic Analytes
August 16th 2024In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.
Reliable Separation and Efficient Group-type Quantitation of Total Petroleum Hydrocarbons (TPHs)
September 11th 2024Petroleum contamination from leaking underground storage tanks, for example, is a significant concern for both the environment and human health. Thorough characterization of the contamination is required to form appropriate risk assessments and remediation strategies, but until now, the determination of total petroleum hydrocarbons (TPHs) in soil has typically involved a convoluted and labour-intensive process. In this article, the analysis of TPH in environmental media is simplified using flow-modulated GC×GC–FID with quantitation based on pre-defined compound groupings. This approach overcomes the drawbacks of conventional solvent fractionation approaches, by eliminating the need for sample fractionation and automating data processing workflows.
The Reality Behind Column Insertion Distance
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