Simon Lomas | Authors
Articles
The Column
Taking Advantage of Sub-2μm Core-Shell Particles for Ultra-Fast and Efficient Urinary Excretion Profiling
Urinary excretion profiling is a key element in the pharmokinetic characterization of new chemical entities (NCEs). Recent advances in ultra-high performance liquid chromatography (UHPLC) column technology offer improved results for liquid chromatography tandem mass spectrometry (LC–MS¬–MS) analysis, enabling rapid quantification of specific drugs and their metabolites in biological matrices.
The Application Notebook
Rapid LC–MS-MS Analysis of Heterocyclic Amines in Salmon
Heterocyclic amines (HCAs) are a class of compounds that are formed when amino acids from meat proteins react with glucose and creatine under high-temperatures, as is associated with frying or grilling over an open flame (1–3). Studies have correlated the consumption of high levels of HCAs with an increased risk of some forms of cancer.