Taking Advantage of Sub-2μm Core-Shell Particles for Ultra-Fast and Efficient Urinary Excretion Profiling

October 24, 2012
Simon Lomas

,
Jeff Layne

The Column

Volume 8, Issue 19
Page Number: 14–17

Urinary excretion profiling is a key element in the pharmokinetic characterization of new chemical entities (NCEs). Recent advances in ultra-high performance liquid chromatography (UHPLC) column technology offer improved results for liquid chromatography tandem mass spectrometry (LC–MS¬–MS) analysis, enabling rapid quantification of specific drugs and their metabolites in biological matrices.

Urinary excretion profiling is a key element in the pharmokinetic characterization of new chemical entities (NCEs). Recent advances in ultra-high performance liquid chromatography (UHPLC) column technology offer improved results for liquid chromatography tandem mass spectrometry (LC–MS) analysis, enabling rapid quantification of specific drugs and their metabolites in biological matrices.

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