This review article summarizes the results obtained from the combined efforts of a joint academic and industrial initiative to solve the real-life challenge of determining low levels of peptide-related impurities in the presence of the related biologically-active peptide at a high concentration.
Retention time fluctuations are challenging to deal with, especially in two-dimensional liquid chromatography (2D‑LC) separations. Here, two approaches are presented that can help navigate this challenge.
Retention time fluctuations are challenging to deal with, especially in two-dimensional liquid chromatography (2D-LC) separations. Here, two approaches are presented that can help navigate this challenge.