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The Application Notebook-09-01-2020
Wyatt Technology - RT-MALS Endpoint Determination of a Polysaccharide Depolymerization Process
September 01, 2020
Medical/Biological
38
9
MALDI Guided SpatialOMx® Uncovers Proteomic Profiles in Tumor Subpopulations of Breast Cancer
September 01, 2020
Medical/Biological
38
9
The timsTOF fleX system bridges a current gap by providing MALDI Imaging and in-depth proteomics analysis in just one instrument. The instrument offers all benefits of a timsTOF Pro for time-efficient and sensitive proteomics, combined with a high-resolution MALDI source and stage. Using PASEF technology, it is possible to retrieve high protein ID rates with small sample amounts. Here we present the new SpatialOMx® workflow to identify distinct proteomic profiles for different tumor subpopulations in breast cancer as an example for this powerful approach.
Chromatotec - Cylinder Free Auto-GC–MS for Continuous SVOCs, VOCs, and PAHs Monitoring in Air
September 01, 2020
Environmental
38
9
Online SPE and Liquid Chromatography–Mass Spectrometry Analysis of Thyroid Hormones in Human Serum
September 01, 2020
Medical/Biological
38
9
Hamilton - Promoter or Polluter? Separation of Triazines on HxSil C18 Column
September 01, 2020
Environmental
38
9
UCT - Analysis of Chloroquine, Hydroxychloroquine, and Desethylchloroquine in Urine Using SPE and LC–MS/MS
September 01, 2020
Medical/Biological
38
9
Postnova - Separation and Sizing of a Virus Mixture Using Asymmetrical Flow Field‐Flow Fractionation Coupled to Multi‐Angle Light Scattering
September 01, 2020
Pharmaceutical/Drug Discovery
38
9
Biogen and Postnova present data on the analysis of adeno-associated viruses (AAV) using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering detection (AF4-MALS). AAV are promising gene therapy delivery vehicles, whose efficacy may be negatively affected by the presence of viral aggregates. Due to its gentle separation and broad applicable size range, AF4-MALS is able to characterize AAV and their aggregates with high resolution and precision, thereby overcoming the drawbacks that column-based chromatography techniques often face when dealing with samples larger than 50 nm in size.