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Articles

Stable Isotope Labelled Internal Standard (SIL-IS) for Analysis of Proteins and mAbs with LC-MS

Quantitative measurement of biotherapeutic and clinically important biomarker proteins using LC-MS/MS has seen great development in the last 15 years. Stable Isotope Labelled Internal Standards are a cornerstone of accurate quantitation and there are several options ranging from signature peptides to “winged” longer peptides or full 13C and/or 15N labelled proteins to choose from. In this video Kevin Ray, Kwasi Mawunyega and Anders Fridstrom will discuss pros and cons with different SIL IS approaches as well as similarities and differences between biopharmaceutical bioanalysis and biomarkers for disease research & diagnosis.

Stable Isotope Labelled Internal Standards (SIL-IS) for Analysis of Proteins and mAbs with LC-MS

Advice from Experts on Developing LC-MS Methods for Biomolecule Analysis

Webcast

Reference Material Development for Testing Infant Formula

Webinar Date/Time: Tuesday, November 29th, 2022 at 11am EST|8am PST|4pm GMT|5pm CET

Webcasts

Addressing the Challenges of PFAS Analysis in a Variety of Matrices: From Air to Zipper Bags

Webinar Date/Time: Fri, Dec 2, 2022 11:00 AM EST

Webcasts

Improved Approaches for Intact and Middle-Up LC-MS Characterization of Biotherapeutics

Wednesday, November 9th, 2022 at 10am EST|7am PST|3pm GMT|4pm CET Chromatographic approaches to intact and middle-up analysis of monoclonal antibodies delving into detailed, more complex strategies for analysis, including ADCs.