Wyatt Technology Corporation | Authors

Articles

SEC-MALS Method for Characterizing mRNA

SEC-MALS quantifies biophysical attributes of mRNA including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.

SEC-MALS and CG-MALS: Complementary Techniques to Characterize Protein-DNA Complexes

This white paper presents the characterization of protein-DNA complexes using two complementary multi-angle light scattering techniques, SEC-MALS and CG-MALS.

Protein Characterization by IEX-MALS

IEX-MALS overcomes some of the restrictions of SEC-MALS that arise from SEC, while providing absolute molar mass, size, and quality assessment of heterogeneous proteins.

Characterizing Lentiviral and Gammaretroviral Vectors by Batch DLS and FFF-MALS

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retrovial viral vectors.

Identification of Insulin Oligomeric States

SEC-MALS identifies monomers, dimers, hexamers, and higher aggregates of insulin to determine optimal formulation, storage, and administration conditions.

AAV Application Notebook: Characterizing AAVs with Light Scattering

Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.