The Column-12-15-2014

The biopharmaceutical industry continues to focus on the development of biotherapeutic monoclonal antibody (mAbs) drugs. In this article, the compatibility of SEC coupled with HRAM–MS for the analysis of mAbs is demonstrated.

In this article, the application of silica monoliths with bimodal pore structure (macro and mesopores) is described for the chromatographic analysis of biomolecules including peptides, proteins, and antibodies.

How to transfer a chromatogram into the molar mass distribution.

Click the title above to open The Column December 15, 2014 North American issue, Volume 10, Number 22, in an interactive PDF format.

Click the title above to open The Column December 15, 2014 Europe & Asia issue, Volume 10, Number 22, in an interactive PDF format.

Scientists at the Norwegian Defence Research Establishment (Kjeller, Norway) are working in collaboration with the University of Oslo (Oslo, Norway) to develop new methods to detect the illicit use of nerve agents. In a recent study published in the journal Analytical Chemistry, the team presented a novel method for the quantification of nerve agent metabolites in human serum and urine by combining salting-out assisted liquid–liquid extraction (SALLE) and on-line solid-phase extraction–liquid chromatography–tandem mass spectrometry (SPE–LC–MS–MS).

A new study published in the Journal of Chromatography A presents metabolite profiling of tea (Camella sinensis) harvested from the Bulang Mountains in Yunnan, China, using multidimensional gas chromatography–mass spectrometry (GC×GC–MS) to determine the impact of seasonal changes.

A new study published in the journal Analytical Chemistry presents a drug metabolism strategy based on microsome mesoporous organosilica nanoreactors coupled with high performance liquid chromatography–mass spectrometry (HPLC–MS) to screen for potential drug toxicity.

Chiron (Trondheim, Norway) has signed an agreement with Kura Biotec (Patagonia, Chile) to distribute their range of enzymes for analytical toxicology.

The Column spoke to Rajmund Michalski from the Polish Academy of Sciences, Institute of Environmental Engineering in Zabrze, Poland, about the application of ion chromatography in speciation analysis.

Selected highlights of innovative chromatography products.

The 3rd African Liquid Chromatography Workshop was held on 6–10 October 2014 in Nairobi, Kenya, at the ChromAfrica Training Centre.