Peter Kilz

Articles by Peter Kilz

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Membranes play an important role in living species as well as in technical processes, including in human care (for example, in kidney treatment). This instalment of Tips & Tricks discusses gel permeation chromatography/size-exclusion chromatography (GPC/SEC) for membrane analysis.

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Gel permeation/size-exclusion chromatography (GPC/SEC) is the standard method for separating samples by molecular size and determining molar mass distributions. However, GPC/SEC instruments can also be used to investigate porous materials and to learn more about pore size distributions, as a powerful alternative to nitrogen gas (N2) adsorption or mercury (Hg) intrusion porosimetry.

GPC/SEC (gel permeation chromatography/size exclusion chromatography) methods generally contain multiple detectors in order to gather more information about the molecular structure of macromolecules.1. Up until now, however, the practice and the impact of detector combination has not been discussed.

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