This article reviews historical bonding techniques still in use for manufacturing high performance liquid chromatography (HPLC) stationary phases today, and also examines some emerging technologies that may be able to tackle unmet needs in novel platforms and phase construction.
A look at how the data system controls the functions of the instrument. The same fundamental electronic principles used to manually control gas chromatographs in the 1970s are still at the center of today’s modern electronically controlled systems.
Charged aerosol detection (CAD) is a powerful complement to ultraviolet (UV) absorbance and mass spectrometric (MS) detection for liquid chromatography (LC), particularly for analytes that have no UV chromophore, or do not ionize well by electrospray ionization. This article explores how to successfully use this technique.
Drug substance development requires a range of analytical methods to be developed to generate process knowledge and to support in-process and release testing throughout a synthetic sequence. This article describes practical examples of a wide variety of transfer challenges and our remediation strategy.
The application of temperature is frequently employed to enhance analytical extractions, especially with solid samples or volatile analytes. This article explores the role of temperature in analytical extractions.
