LCGC Europe-07-01-2018
LCGC Europe
Vol 31 No 7 LCGC Europe July 2018 Regular Issue PDF
July 01, 2018
Issue PDF
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Click the title above to open the LCGC Europe June 2018 regular issue in an interactive PDF format.
Profiling Nonionic Surfactants Applied in Pharmaceutical Formulations Using Comprehensive Two-Dimensional LC with ELSD and MS Detection
July 01, 2018
Features
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Comprehensive two-dimensional liquid chromatography (2D-LC) was used for detailed profiling of various nonionic ethoxylated surfactants applied in pharmaceutical formulations. Hydrophilic-interaction chromatography (HILIC) and reversed-phase liquid chromatography (LC) were used as the first and second dimensions, respectively. Detection was performed with evaporative light-scattering detection (ELSD) for general profiling and with single-quadrupole mass spectrometry (MS) for structure elucidation of individual peaks and for class-type confirmation of peak-groups.
When Do We Need Sub-2-µm Superficially Porous Particles for Liquid Chromatography Separations?
July 01, 2018
Column Watch
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The use of superficially porous particles (SPPs) for modern high performance liquid chromatography (HPLC) is now very common. Initially, SPPs rose as an alternative to sub-2-µm fully porous particles (FPPs). In recent years, many column manufacturers have developed 2-µm and smaller SPP-based products. This article investigates the practical utility of these smaller SPP designs.
Split, Splitless, and Beyond—Getting the Most From Your Inlet
July 01, 2018
GC Connections
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While capillary gas chromatography has been undergoing a renaissance, with new columns, detectors, data systems, and multidimensional separations, the classical inlets have remained the same: We are still injecting liquid samples with syringes into split and splitless inlets, as we have for nearly 50 years. Split and splitless injections present several well-known and some not-so-well known challenges, mostly arising from heating of the inlet, that make sample injection and inlets a major hurdle for gas chromatographers. These challenges and some ideas for mitigating them are discussed and a case is made for renewed exploration of the cool inlets and injection techniques: cool on-column and programmed temperature vaporization.
The 32nd International Symposium on Chromatography (ISC 2018)
July 01, 2018
Events
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The 32nd International Symposium on Chromatography (ISC 2018) will be held on 23–27 September 2018 in Cannes-Mandelieu, France.
Data Integrity and USP : Part 1 Specifications and Suppliers
July 01, 2018
Questions of Quality
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This is the first of three articles looking at the impact of the new United States Pharmacopeia (USP) chapter on Analytical Instrument Qualification (AIQ) on data integrity in a regulated chromatography labora-tory. In part 1, user specifications for chromatography systems and the relationship between users and sup-pliers will be discussed.
Separation Science: Driving Pharmaceutical Development and Manufacture
July 01, 2018
Events
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The Chromatographic Society and the Royal Society of Chemistry Analytical Division North East Region has organized a meeting to be held on 22 November 2018 in the Stadium of Light, Sunderland, UK.