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LCGC Europe-09-01-2018

LCGC Europe

Vol 31 No 9 LCGC Europe September 2018 Regular Issue PDF

September 01, 2018

Issue PDF

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Click the title above to open the LCGC Europe September 2018 regular issue in an interactive PDF format.

Fundamental and Practical Aspects of Liquid Chromatography and Capillary Electromigration Techniques for the Analysis of Phenolic Compounds in Plants and Plant-Derived Food, Part 1: Liquid Chromatography

September 01, 2018

Cover Story

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Column-based liquid phase separation techniques, such as liquid chromatography (LC) in reversed phase separation mode and capillary electromigration techniques, using continuous electrolyte systems, are widely used for the identification and quantification of phenolic compounds in plants and food matrices of plant origin. This paper is the first of a two-part review article discussing fundamental and practical aspects of both LC and capillary electromigration techniques used for the analysis of phenolic compounds occurring in plant-derived food and in edible and medicinal plants. The chemical structure and distribution of the major phenolic compounds occurring in the plant kingdom, as well as the main methods used for their extraction and sample preparation, are also discussed. Part 1 will focus on liquid chromatography.

Safely Delivering the Best Possible Carrier and Detector Gases to Your GC System

September 01, 2018

GC Troubleshooting

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The quality of a gas chromatogram depends heavily on the quality of the separation and detection gases, among many other factors. In this month’s instalment, “GC Connections” discusses ways in which chromatographers can ensure a safe working environment while delivering gases that are up to the requirements of the separations at hand, in the context of moving a laboratory to a new location.

Data Integrity and USP , Part 2: OQ Supervision and Execution

September 01, 2018

Questions of Quality

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This is the second of three articles looking at the impact of the new United States Pharmacopeia (USP) on analytical instrument qualification (AIQ) on data integrity in a regulated chromatography laboratory. This part focuses on how the laboratory should supervise the execution of operational qualification (OQ) protocols by a third-party service provider. The principles described also apply to in-house metrology departments.

LC–MS Sensitivity: Practical Strategies to Boost Your Signal and Lower Your Noise

September 01, 2018

Column Watch

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Liquid chromatography–mass spectrometry (LC–MS) has become the preferred analytical technique for many challenging assays based on its selectivity, sensitivity, and broad applicability to compounds of varying polarity. Despite its advantages, the complexity of LC–MS systems often leaves analysts struggling to meet method detection limits. In this instalment of “Column Watch”, several strategies will be discussed to improve method sensitivity through the reduction of contaminants, the careful selection of LC method conditions, and the optimization of MS interface settings. By understanding the relationship between these parameters and ionization efficiency, analysts can enhance their signal-to-noise ratio and realize the hidden potential of their LC–MS.