LCGC Europe-11-01-2013
LCGC Europe
A Multimodal Liquid and Supercritical Fluid Chromatography Chiral Separation Screening and Column Maintenance Strategy Designed to Support Molecules in Pharmaceutical Development (Part 1)
November 01, 2013
Cover Story
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Chiral separation screening has become a widely accepted approach for the rapid identification of an appropriate chiral stationary phase for use in more focused enantioseparation optimization. A set of extended screens encompassing various chromatographic modes using HPLC and SFC is presented.
More Myths in Ultrahigh-Pressure Liquid Chromatography
November 01, 2013
Perspectives in Modern HPLC
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This instalment describes more popular myths or half-truths in UHPLC and provides data that contradict or even repudiate some of these commonly held beliefs.
Practical Gas Chromatography
November 01, 2013
GC Connections
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Questions about how practical proposed gas chromatography (GC) method changes are often come up during optimization for speed and resolution, or while converting to a different carrier gas. Related objective measurements such as the optimum practical carrier gas velocity were defined more than 40 years ago. This instalment reviews such metrics in the light of their relevance to today's GC challenges.
The Top 10 HPLC and UHPLC Column Myths: Part 2
November 01, 2013
Column Watch
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In the final part, the top 10 HPLC and UHPLC column myths are presented and attempts are made to demystify them by offering some evidence that they are untrue. This part will feature myths five to one.
Mobile Phase Optimization Strategies in Reversed-Phase HPLC
November 01, 2013
The Essentials
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There are many ways to improve retention or selectivity in reversed-phase HPLC and knowledge of the key eluent variables to achieve this is essential reading.
What's the Problem with the LLOQ? — A Case Study
November 01, 2013
LC Troubleshooting
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Two different methods of calculating the LLOQ disagree. Which, if either, is correct?
Vol 26 No 11 LCGC Europe November 2013 Regular Issue PDF
November 01, 2013
Issue PDF
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Click the title above to open the LCGC Europe November 2013 regular issue, Vol 26 No 11, in an interactive PDF format.