LCGC North America-08-01-2015

LCGC North America

The Ideal Chromatography Data System for a Regulated Laboratory, Part I: The Compliant Analytical Process

August 01, 2015

Peer-Reviewed Article

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This is the first of a four part series looking at what functions and features the authors believe should be in a future chromatography data system (CDS) working within a regulated analytical laboratory. The first part of this series is aimed at setting the scene of where and how a CDS fits within the laboratory operation. In using the term CDS, in the future, this can refer to either a traditional CDS that is familiar to readers or the CDS functions could form part of another informatics solution such as Electronic Laboratory Notebook (ELN) or Laboratory information Management System (LIMS). In the next three parts we make 15 recommendations for improvements to the system architecture, the requirements for electronic working and regulatory compliance.

Separation Science in Drug Development, Part II: High-Throughput Characterization

August 01, 2015

Perspectives in Modern HPLC

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This installment provides an overview of high-throughput characterization techniques of drug leads to support small molecule drug discovery programs in a pharmaceutical company. A myriad of analytical chemistry techniques including separation science methodologies are used to confirm the structures and identities, quantitating the concentrations of stock solutions, and measuring key physicochemical properties of the new chemical entities (NCE). A case study is used here to illustrate the details of these applications in high-throughput characterization.

Living Off the Fat of the Land

August 01, 2015

Sample Prep Perspectives

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Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh-Dyer and Folch lipid extraction methods from the late 1950s. This month we will take a look at the lasting impact of these papers and explore the current state of lipid extractions, including lipidomics.

Detecting Substandard Drugs in Africa

August 01, 2015

Chromatography Corner

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Mélisande Bernard is developing chromatographic methods to detect substandard cardiovascular drugs in Africa.

Vol 33 No 8 LCGC North America August 2015 Regular Issue PDF

August 01, 2015

Issue PDF

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Click the title above to open the LCGC North America August 2015 regular issue, Vol 33 No 8, in an interactive PDF format.