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LCGC North America-08-01-2015
LCGC North America
The Ideal Chromatography Data System for a Regulated Laboratory, Part I: The Compliant Analytical Process
August 01, 2015
Peer-Reviewed Article
33
8
This is the first of a four part series looking at what functions and features the authors believe should be in a future chromatography data system (CDS) working within a regulated analytical laboratory. The first part of this series is aimed at setting the scene of where and how a CDS fits within the laboratory operation. In using the term CDS, in the future, this can refer to either a traditional CDS that is familiar to readers or the CDS functions could form part of another informatics solution such as Electronic Laboratory Notebook (ELN) or Laboratory information Management System (LIMS). In the next three parts we make 15 recommendations for improvements to the system architecture, the requirements for electronic working and regulatory compliance.
Developing HPLC Methods for Biomolecule Analysis
August 01, 2015
The Essentials
33
8
Gain an invaluable insight into the key methods that are used for biomolecule characterization, process control, and release testing
Overload in Liquid Chromatography
August 01, 2015
LC Troubleshooting
33
8
How to distinguish between LC column overload and detector overload.
Separation Science in Drug Development, Part II: High-Throughput Characterization
August 01, 2015
Perspectives in Modern HPLC
33
8
This installment provides an overview of high-throughput characterization techniques of drug leads to support small molecule drug discovery programs in a pharmaceutical company. A myriad of analytical chemistry techniques including separation science methodologies are used to confirm the structures and identities, quantitating the concentrations of stock solutions, and measuring key physicochemical properties of the new chemical entities (NCE). A case study is used here to illustrate the details of these applications in high-throughput characterization.
The New Face of SFC: Why Analysts Should Take Another Look
August 01, 2015
Guest Editorial
33
8
What exactly is SFC? Although you may have heard and read much about it recently, it is still rather vague to many a chromatographer.
Living Off the Fat of the Land
August 01, 2015
Sample Prep Perspectives
33
8
Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh-Dyer and Folch lipid extraction methods from the late 1950s. This month we will take a look at the lasting impact of these papers and explore the current state of lipid extractions, including lipidomics.
A Life with the Boys
August 01, 2015
In Memoriam
33
8
A memoir of Phyllis Brown-a pioneering chromatographer, a devoted mentor, and a champion for women in science
Wolfgang Lindner: Reflections on a Career with a Chiral Center
August 01, 2015
History of Chromatography
33
8
Professor Wolfgang Lindner spoke to LCGC Editorial Advisory Board member Kevin A. Schug about his inspiring and influential career in chromatography.
Detecting Substandard Drugs in Africa
August 01, 2015
Chromatography Corner
33
8
Mélisande Bernard is developing chromatographic methods to detect substandard cardiovascular drugs in Africa.
Vol 33 No 8 LCGC North America August 2015 Regular Issue PDF
August 01, 2015
Issue PDF
33
8
Click the title above to open the LCGC North America August 2015 regular issue, Vol 33 No 8, in an interactive PDF format.