LCGC North America-08-01-2015

This is the first of a four part series looking at what functions and features the authors believe should be in a future chromatography data system (CDS) working within a regulated analytical laboratory. The first part of this series is aimed at setting the scene of where and how a CDS fits within the laboratory operation. In using the term CDS, in the future, this can refer to either a traditional CDS that is familiar to readers or the CDS functions could form part of another informatics solution such as Electronic Laboratory Notebook (ELN) or Laboratory information Management System (LIMS). In the next three parts we make 15 recommendations for improvements to the system architecture, the requirements for electronic working and regulatory compliance.

Gain an invaluable insight into the key methods that are used for biomolecule characterization, process control, and release testing

How to distinguish between LC column overload and detector overload.

This installment provides an overview of high-throughput characterization techniques of drug leads to support small molecule drug discovery programs in a pharmaceutical company. A myriad of analytical chemistry techniques including separation science methodologies are used to confirm the structures and identities, quantitating the concentrations of stock solutions, and measuring key physicochemical properties of the new chemical entities (NCE). A case study is used here to illustrate the details of these applications in high-throughput characterization.

What exactly is SFC? Although you may have heard and read much about it recently, it is still rather vague to many a chromatographer.

Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh-Dyer and Folch lipid extraction methods from the late 1950s. This month we will take a look at the lasting impact of these papers and explore the current state of lipid extractions, including lipidomics.

A memoir of Phyllis Brown-a pioneering chromatographer, a devoted mentor, and a champion for women in science

Professor Wolfgang Lindner spoke to LCGC Editorial Advisory Board member Kevin A. Schug about his inspiring and influential career in chromatography.  

Mélisande Bernard is developing chromatographic methods to detect substandard cardiovascular drugs in Africa.

Click the title above to open the LCGC North America August 2015 regular issue, Vol 33 No 8, in an interactive PDF format.