LCGC North America-08-01-2018

Click the title above to open the LCGC North America August 2018 regular issue in an interactive PDF format.

Blanks are important in the pursuits of quality control and robust quantitative analytical methods, but many analysts don’t fully understand their value, or how to use them correctly.

We examine instances where contaminants are problematic in LC–MS, as well as successful methods to decrease their influence.

These ten propositions are widely acknowledged, but frequently neglected, by practitioners of high performance liquid chromatography (HPLC).

We look at a process that can overcome the shortcomings associated with liquid–liquid extraction.

Biomimetic HPLC retention data can be used to measure how a compound will bind to proteins and phospholipids in vivo.

We explore the developments that have made it possible to produce sub-minute, and, more recently, even sub-second enantiomeric separations. We also look at the questions that remain unanswered.

The series continues with a crucial scientific and regulatory necessity in ensuring reliable information-the second-person review.

The theoretical plate concept forms the basis of chromatographic theory. Here is where it came from.