LCGC North America-08-01-2020

August 01, 2020

Here we provide an overview of the fundamentals and best practices on the development of stability-indicating HPLC methods for drug substances and products. We explain both traditional and easier modern approaches to developing stability-indicating HPLC methods—including using a universal generic method for new chemical entities—and address regulatory considerations and life cycle management strategies.

August 01, 2020

Click the title above to open the LCGC North America August 2020 issue, Volume 38, Number 8, in an interactive PDF format.

August 01, 2020

When forced to teach separation science with little or no access to a laboratory, chromatography simulators can help. Here, we describe several that are both useful and free.

August 01, 2020

A U.S. government-sponsored report released last year puts a spotlight on critical concerns affecting the future of separation science.

August 01, 2020

In electromembrane extraction (EME), the target analyte is extracted from an aqueous sample across a supported liquid membrane (SLM) and analyzed using LC. Through the study presented here, we demonstrate the principles of the technique and test its performance.

August 01, 2020

Low-pressure gas chromatography (LPGC)–MS should be the first option in many GC–MS applications to provide fast, sensitive, and robust analyses; and the installation, instrumentation, and implementation of LPGC is possible in any GC–MS system.

August 01, 2020

If you are analyzing metal-sensitive biomolecules, and a bioinert instrument is unavailable, or insufficient, passivation or mobile-phase additives may help. Here’s how to use those solutions, with tips for avoiding potential pitfalls.