LCGC North America-10-01-2002

Guest author Steve Griffin identifies the fundamental problems in capillary manufacturing techniques that cause capillary defects and suggests some corrective actions.

John Hinshaw discusses the measurement of column flow and its interrelationship with carrier-gas velocity.

Leslie Ettre remembers A.J.P. Martin, inventor of partition, paper, reversed-phase, and gas–liquid partition chromatography.

This article provides theoretical background, experimental data, and practical considerations about the effects of organic modifiers on analyte ionization in reversed-phase LC.

John Dolan examines problems associated with adjusting gradients in reversed-phase LC.

Letters about calculating peak asymmetry and gas cylinder safety.

Tim Wehr looks at the requirements of multidimensional LC and provides examples of some systems used in proteomics.

The authors studied the retention behavior of reversed-phase HPLC columns under 100% aqueous mobile-phase conditions.