LCGC North America-10-01-2019

The authors provide a technical overview of the design and operating principles of variable wavelength and photodiode array detectors, and include historical perspectives and common practices in operation and maintenance.

In this installment, tips, tricks, and suggestions are provided for best practices in reversed-phase separations, in both 1D and 2D LC, with gradient elution for minimum variations in retention time.

How does one meet the most demanding part of an analysis-sampling? A typical example is soil, which presents a twofold problem for the analyst: first, the selection of the sites where the samples are taken, and second, the reduction of a sample (for example, 1 kg) to the analysis aliquot size (for example, 10 μL). This paper describes the details of sampling issues.

An essential tool for troubleshooting and tuning GC–MS instruments is the tune report; this article explains the meaning and uses of this report when combined with a tuning compound.

Here, we review the regulatory expectations of metrics for monitoring data integrity and discuss their practical implementation in a regulated chromatography laboratory.

Click the title above to open the LCGC North America October 2019 issue, Volume 37, Number 10, in an interactive PDF format.