LCGC North America-12-01-2019

Click the title above to open the LCGC North America December 2019 issue, Volume 37, Number 12, in an interactive PDF format.

A deeper theoretical understanding the relationship between peak area and flow rate will help analysts diagnose problems when using UV absorbance detection.

This technical overview of chromatography data systems (CDS) looks at how CDS are designed, how they can be used most effectively, and what developments we can expect in the future.

The potential of food packaging components to migrate into food is an important health concern. Perfecto Paseiro Losada and his group at the University of Santiago de Compostela, in Spain, have been investigating the migration kinetics and actual migration of such compounds into a variety of types of food. They also have been carrying out studies to estimate dietary exposure. Paseiro recently spoke to LCGC about this work.

Fundamentals aspects of using HPLC techniques for protein analysis are described as they relate to the analysis of post-translational modifications (PTMs) and glycoprofiles.

Gas chromatography–mass spectrometry (GC–MS), reversed-phase LC with stop-flow fluorescence (FL), and constant energy synchronous fluorescence spectroscopy (CESFS) are explored to determine PAH isomers in three combustion-related standard reference materials.

Clinical metabolomics requires analytical methods that provide both high resolution and high throughput. In this review, we assess the promise of a variety of techniques-including HILIC, SFC, multidimensional LC, ion-mobility mass spectrometry, and data-independent acquisition mass spectrometry methods-to meet those needs.