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October 2022 | LCGC North America
Essentials of LC Troubleshooting, Part V: What Happened to My Sensitivity?
October 01, 2022
Column: LC Troubleshooting
40
10
There are various physical and chemical causes of low detection sensitivity. Here, we address some of these causes, and how to troubleshoot them.
Application of Porous Layer Open Tubular Columns: Beyond Permanent Gases
October 01, 2022
Column: Column Watch
40
10
The application of porous layer open tubular (PLOT) columns can be expanded beyond light compounds to separations of analytes with heavier boiling points.
Analytical Characterization of Host Cell Proteins (HCPs)
October 01, 2022
Column: Focus on Biopharmaceutical Analysis
40
10
In response to regulatory concerns, host cell protein (HCP) analysis is now often conducted using LC–MS/MS. Unlike ELISA, LC–MS/MS can positively identify and quantify specific HCPs and characterize the total amount of HCPs present.
Multidimensional Gas Chromatography: Benefits and Considerations for Current and Prospective Users
October 01, 2022
Columns
40
10
When should multidimensional GC approaches be used for analyzing complex samples and analytes?
Drug Development Process: Nonclinical Development of Small-Molecule Drugs
October 01, 2022
Column: Perspectives in Modern HPLC
40
10
This case study of the career path of a separation scientist illustrates the diversified roles of an analytical chemist in nonclinical drug development.
The Return of the HPLC Conference – A Viewpoints Column
October 01, 2022
40
10
The return of the in-person HPLC Conference was welcomed by the separation science community. There were a lot of developments to share.
Determination of Polychlorinated Biphenyls in Water Samples Using a Needle Trap Device Combined with Gas Chromatography
October 01, 2022
40
10
The method presented here, which uses a novel needle trap device (NTD) with sol-gel PEG-coated fibers in conjunction with GC, is a simple, inexpensive, and accurate tool for the analysis of trace levels of PCBs in water samples.