October 2022

There are various physical and chemical causes of low detection sensitivity. Here, we address some of these causes, and how to troubleshoot them.

The application of porous layer open tubular (PLOT) columns can be expanded beyond light compounds to separations of analytes with heavier boiling points.

In response to regulatory concerns, host cell protein (HCP) analysis is now often conducted using LC–MS/MS. Unlike ELISA, LC–MS/MS can positively identify and quantify specific HCPs and characterize the total amount of HCPs present.

When should multidimensional GC approaches be used for analyzing complex samples and analytes?

This case study of the career path of a separation scientist illustrates the diversified roles of an analytical chemist in nonclinical drug development.

The return of the in-person HPLC Conference was welcomed by the separation science community. There were a lot of developments to share.

The method presented here, which uses a novel needle trap device (NTD) with sol-gel PEG-coated fibers in conjunction with GC, is a simple, inexpensive, and accurate tool for the analysis of trace levels of PCBs in water samples.