State-of-the-Art Biopharmaceutical Analysis
The articles presented here highlight important recent developments in biopharmaceutical analysis.
Improving Selectivity in the Chromatographic Analysis of Monoclonal Antibodies (mAbs) Through the Use of Multi-Isocratic Elution Mode
Multi-isocratic elution mode is a powerful chromatographic approach for characterizing minor isoforms of monoclonal antibodies.
Analytical Applications of Immobilized Enzyme Reactors (IMERs) Coupled to LC–MS/MS for Bottom- and Middle-Up Characterization of Proteins
Flow-through immobilized-enzyme reactors (IMERs) can streamline protein digestion for bottom- and middle-up LC–MS characterization while providing high accuracy and reproducibility.
The Power of Trypsin Immobilized Enzyme Reactors (IMERs) Deployed in Online MDLC–MS Applications
Commercially available trypsin IMERs can digest proteins with high sequence coverage and robustness, facilitating online multidimensional LC–MS.
Online HPLC–HRMS Platform: The Next-Generation Process Analytical Technology Tool for Real-Time Monitoring of Antibody Quality Attributes in Biopharmaceutical Processes
Leading biopharmaceutical companies are integrating HPLC into production processes for monitoring critical quality attributes (CQAs) with high-resolution mass spectrometry (HRMS) detection.
Recent Developments in Biopharmaceutical Analysis European PDF
Click the image below to access the LCGC Europe Supplement 'Recent Developments in Biopharmaceutical Analysis'
Multi-Attribute Monitoring and the Multi-Attribute Method: A Powerful Double Act for Supporting Biopharmaceutical Manufacturing
This work compares at-line Protein A-MS with a standard multi-attribute method (MAM) workflow for analyzing product quality attributes (PQAs) during upstream processing.
New Aspects in the Integration of MS Technologies in the Biopharmaceutical Industry
High-resolution mass spectrometry (HRMS) is an increasingly critical tool for identifying, characterizing, and monitoring attributes of protein-based therapeutics.
Perspectives on the Use of Retention Modeling to Streamline 2D-LC Method Development: Current State and Future Prospects
If we are going to achieve widespread adoption of multidimensional separations, we need more systematic approaches to method development that rely less on user experience.
