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Recent Developments in Biopharmaceutical Analysis | LCGC Supplements
State-of-the-Art Biopharmaceutical Analysis
April 01, 2022
40
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The articles presented here highlight important recent developments in biopharmaceutical analysis.
Improving Selectivity in the Chromatographic Analysis of Monoclonal Antibodies (mAbs) Through the Use of Multi-Isocratic Elution Mode
April 01, 2022
40
s4
Multi-isocratic elution mode is a powerful chromatographic approach for characterizing minor isoforms of monoclonal antibodies.
Analytical Applications of Immobilized Enzyme Reactors (IMERs) Coupled to LC–MS/MS for Bottom- and Middle-Up Characterization of Proteins
April 01, 2022
40
s4
Flow-through immobilized-enzyme reactors (IMERs) can streamline protein digestion for bottom- and middle-up LC–MS characterization while providing high accuracy and reproducibility.
The Power of Trypsin Immobilized Enzyme Reactors (IMERs) Deployed in Online MDLC–MS Applications
April 01, 2022
40
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Commercially available trypsin IMERs can digest proteins with high sequence coverage and robustness, facilitating online multidimensional LC–MS.
Online HPLC–HRMS Platform: The Next-Generation Process Analytical Technology Tool for Real-Time Monitoring of Antibody Quality Attributes in Biopharmaceutical Processes
April 01, 2022
40
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Leading biopharmaceutical companies are integrating HPLC into production processes for monitoring critical quality attributes (CQAs) with high-resolution mass spectrometry (HRMS) detection.
Recent Developments in Biopharmaceutical Analysis European PDF
April 01, 2022
Issue PDF
40
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Click the image below to access the LCGC Europe Supplement 'Recent Developments in Biopharmaceutical Analysis'
Multi-Attribute Monitoring and the Multi-Attribute Method: A Powerful Double Act for Supporting Biopharmaceutical Manufacturing
April 01, 2022
40
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This work compares at-line Protein A-MS with a standard multi-attribute method (MAM) workflow for analyzing product quality attributes (PQAs) during upstream processing.
New Aspects in the Integration of MS Technologies in the Biopharmaceutical Industry
April 01, 2022
40
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High-resolution mass spectrometry (HRMS) is an increasingly critical tool for identifying, characterizing, and monitoring attributes of protein-based therapeutics.
Perspectives on the Use of Retention Modeling to Streamline 2D-LC Method Development: Current State and Future Prospects
April 01, 2022
40
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If we are going to achieve widespread adoption of multidimensional separations, we need more systematic approaches to method development that rely less on user experience.