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|Articles|October 7, 2011

Column

  • The Column-10-07-2011
  • Volume 7
  • Issue 18

Accelerating Proteomic Biomarker Validation

The optimum in proteomics research today is in validating the performance of promising biomarkers across large biological sample sets. Many new strategies have been developed in recent years to improve and accelerate targeted MS verification assays.

The optimum in proteomics research today is in validating the performance of promising biomarkers across large biological sample sets. Many new strategies have been developed in recent years to improve and accelerate targeted MS verification assays. One of the more promising strategies involves combining column-switching techniques for multiplexed nano‑LC with MS instrumentation and software that performs time-scheduled multiple reaction monitoring (MRM). In this article we will demonstrate an effective workflow that incorporates advanced LC and MS techniques to significantly improve throughput and accelerate biomarker verification.

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Articles in this issue

almost 15 years ago

Healthy spaghetti

almost 15 years ago

Separations in the Food Industry

almost 15 years ago

Water contamination collaboration

almost 15 years ago

CESI–MS: An Essential Complement to Nano LC–ESI–MS for Complex Proteome Analysis

almost 15 years ago

Tackling myeloma drug resistance

almost 15 years ago

$1.2 million NASA grant for chromatographer

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