Accelerating Proteomic Biomarker Validation

October 7, 2011

The Column

The Column, The Column-10-07-2011, Volume 7, Issue 18

The optimum in proteomics research today is in validating the performance of promising biomarkers across large biological sample sets. Many new strategies have been developed in recent years to improve and accelerate targeted MS verification assays.

The optimum in proteomics research today is in validating the performance of promising biomarkers across large biological sample sets. Many new strategies have been developed in recent years to improve and accelerate targeted MS verification assays. One of the more promising strategies involves combining column-switching techniques for multiplexed nano‑LC with MS instrumentation and software that performs time-scheduled multiple reaction monitoring (MRM). In this article we will demonstrate an effective workflow that incorporates advanced LC and MS techniques to significantly improve throughput and accelerate biomarker verification.

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