Agilent CrossLab

Scientists at the Indian Institute of Technology Delhi recently created a new machine learning (ML)-based tool for process verification during process chromatography unit operations.

In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.

Scientists recently studied how different factors affect antisense oligonucleotides (ASOs) under hydrophilic interaction liquid chromatography (HILIC) conditions.

Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.

Data Intelligence software offers curated insights through customized dashboards for streamlined, well-organized, and timely access to critical laboratory information.

The American Chemical Society (ACS) released its new strategic plan, which reinforces the organization’s mission to improve lives through the power of chemistry.