News|Articles|July 29, 2025

Analysis of Per-and Polyfluoroalkyl Substances (PFAS) in Leachate by EPA Method 1633A Using LC-MS/MS

EPA Method 1633A is currently the only validated multi-lab method for PFAS detection in leachate. This poster demonstrates the effectiveness of a system to provide robust, stable performance over 154 injections and 37 hours of continuous PFAS analysis, making it ideal for routine monitoring of complex leachate matrices.


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
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