Application Note: AAV Application Notebook

This application note demonstrates the use of Thermal Desorption as greener approach for sampling of terpenes in air for workplace exposure or terpene profiling

This application note demonstrates the use of Thermal Desorption as a greener approach for sampling of terpenes in the air for workplace exposure or terpene profiling

GC×GC–TOF MS with thermal modulation used to provide detailed and sensitive characterisation of pyrolysis oil composition to identify possible contaminants.

This application note showcases a Biozen dSEC-7 SEC chemistry/fluorescence detector solution, offering reliable AAV aggregate analysis in under 10 minutes with as little as 0.5 µL of sample. Across four AAV serotypes, resolution between monomer and aggregates remains consistently high, emphasizing Biozen dSEC-7's efficiency and ability to maintain accurate detection at minimal injection volumes. Ideal for routine testing, this solution ensures precise measurement of a CQA with streamlined sample consumption.

With its 700 Å large pore silica particle and hydrophilic diol-type surface chemistry, Biozen dSEC-7 provides excellent resolution of monomer from dimer peaks in under 8 minutes across four different AAV serotypes. This capability is crucial for optimizing gene therapy biopharmaceuticals, ensuring thorough analytical scrutiny to select the most appropriate serotype(s) for enhanced therapeutic outcomes and immunogenic profiles.

Analysis of VPH in environmental samples by automated flow-modulated headspace–GC×GC–FID, for robust and efficient sample quantitation.