ASMS Monday Afternoon Session: Fundamentals of Ionization

The afternoon oral session titled “Fundamentals of Ionization” will be held from 2:30 to 4:30 pm in the auditorium. The session, which will be chaired by Fanny C. Liu of Florida State University, will cover a variety of aspects relating to ionization.

Lars Konermann of Western University will kick off the session by discussing a molecular dynamics (MD) strategy that can capture the unique properties of protons in water, which provides novel insights into electrospray ionization (ESI) mechanisms.

Next, Debasmita Ghosh from the Université de Bordeaux will talk about how we can better understand the mechanism of native supercharging for nucleic acids in physiological conditions through the utilization of unstructured or structured G-quadruplex nucleic acids, formed by guanine-rich sequences and stabilized by the coordination of specific cations.

The third talk, by Florian Schlottmann of Leibniz University Hannover will explain how high kinetic energy ion mobility spectrometers (HiKE-IMS) show improvements in linearity, number of detectable substances, and reduced cross sensitivities compared to ambient pressure drift tube IMS.

Marcos Bouza Areces of the University of Jaen will then report the measurement of ion internal energy distributions for four different plasma ionization sources using benzyl ammonium thermometer (TM) ions.

Madison Edwards of Texas A&M University will present a newly developed interfacial microreactor that has been used for accelerating electrochemical reactions and aiding in lipid identification with the resolution of carbon-carbon double-bond positions.

The session will wrap up with a talk from Anyin Li of the University of New Hampshire, who will discuss the application of ultralow current ionization to the direct analysis of highly concentrated protein samples in manufacturing matrices and how the observed characteristics shed light on how femtoESI could synergize with other advancements in MS.