The addition of extra detectors such as light scattering and intrinsic viscosity to a single-detector size-exclusion chromatography system or, better still, the use of an integrated multi-detector size-exclusion chromatography system can pay significant dividends in the breadth of sample information generated.
The addition of extra detectors such as light scattering and intrinsic viscosity to a single-detector size-exclusion chromatography system or, better still, the use of an integrated multi-detector size-exclusion chromatography system can pay significant dividends in the breadth of sample information generated. This leads to a greater understanding of molecular weight, structure and composition, and hence can shorten the time required for process optimization.
Molecular weight can be measured independently of sample retention volume, eliminating the issues of column calibration, and intrinsic viscosity provides a direct measure of sample structure. The addition of a second concentration detector allows compositional information to be obtained. This webcast will provide an overview of multi-detector technologies and how they can benefit applications such as synthetic polymers, polysaccharides and proteins.
Sponsored by: Malvern Instruments
Inside the Laboratory: The Gionfriddo Group at the University at Buffalo
March 28th 2024In this edition of “Inside the Laboratory,” Emanuela Gionfriddo, PhD, an associate professor of chemistry at the University at Buffalo, discusses her group’s current research endeavors, including using solid-phase microextraction (SPME) coupled to liquid chromatography (LC) and gas chromatography (GC) to further understand the chemical relationship between environmental exposure and disease and elucidate micropollutants fate in the environment and biological systems.
Transferring Methods to Compact and Portable HPLC
February 14th 2024The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.