News|Articles|July 29, 2025

Comprehensive Non-Targeted PFAS Analysis Using Quadrupole Time-of-Flight (QToF) LCMS

This poster presents a comprehensive, multi-approach data processing method for the analysis of non-targeted PFAS in both positive and negative ionization modes. Results show this three-pronged approach gave comprehensive identifications without excess false positives.


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
Basel, Switzerland. Old town with red stone Munster cathedral on the Rhine river. © SCStock - stock.adobe.com
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