Coupling MALS and SAXS for Time-resolved Studies of Biopolymeric Filamentous Networks Assembly: Fibrin Formation

Multi-angle light scattering (MALS) is primarily used to determine molecular weight, size-and shape-related parameters of macromolecules or nanoparticles as they elute from a separation device. In batch (unfractionated) mode, MALS provides the weight-average molecular weight wand the z-average mean square radius z. The DAWNHELEOSIIis particularly well suited for these tasks owing to its flow cell design, holding a mere ~67µl and readily connecting toa fluid line through HPLC-type fittings.