Determination of Aminoglycoside Antibiotics by HPLC with ELSD

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Aminoglycoside antibiotics are complex organic molecules produced by streptomyces strains and are extremely important in clinical medicine, due to their efficacy and low cost. The separtation of streptomycin and neomycin requires the use of an ion-pair reagent in the mobile phase, which demands special attention when using ELSD.