Determination of Aminoglycoside Antibiotics by HPLC with ELSD
Aminoglycoside antibiotics are complex organic molecules produced by streptomyces strains and are extremely important in clinical medicine, due to their efficacy and low cost. The separtation of streptomycin and neomycin requires the use of an ion-pair reagent in the mobile phase, which demands special attention when using ELSD.
Emerging Trends and Challenges in Detecting Residues and Contaminants in Food in the Exposome Era
June 18th 2025This article describes the analytical challenges of chemical exposomics in food safety. The need for high-throughput, multi-platform approaches—such as LC–HRMS and GC–HRMS with IMS—to capture the full spectrum of potential contaminants in our food supply is emphasised.
New Research Explores Role of Nucleotide Hydrophobicity in Oligonucleotide Separation
June 18th 2025Researchers from Waters and Biospring studied the contribution of nucleotide type and modifications on the retention and resolution of 22–24 nt long oligonucleotides in different chromatographic methods.
A Life Measured in Peaks: Honoring Alan George Marshall (1944–2025)
June 18th 2025A pioneer of FT-ICR Mass Spectrometry, Alan G. Marshall (1944–2025), is best known for co-inventing Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), a transformative technique that enabled ultrahigh-resolution analysis of complex mixtures. Over a career spanning more than five decades at institutions like the University of British Columbia, The Ohio State University, and Florida State University, he published over 650 peer-reviewed papers and mentored more than 150 scientists. Marshall’s work profoundly impacted fields ranging from astrobiology to petroleomics and earned him numerous prestigious awards and fellowships. Revered for his intellect, mentorship, and dedication to science, he leaves behind a legacy that continues to shape modern mass spectrometry.
