News|Articles|January 21, 2026
Efficient Method Development for Separation of Antibody Charge Variants by Ion-Exchange Chromatography
Author(s)Shimadzu Corporation
This article describes how to efficiently achieve the optimal peak separation for charge variants of a monoclonal antibody using pH gradient ion-exchange chromatography and LabSolutions MD, dedicated software that can automate the entire method development workflow, including the generation of an analysis schedule, mobile phase preparation, and data processing.
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