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News|Articles|January 22, 2024
Heat and High pH Forced Degradation of Antibodies on a Biozen dSEC-2 Column
Author(s)Phenomenex, Inc.
This application note demonstrates the applicability of the Biozen dSEC-2 column in understanding the biophysical integrity monoclonal antibodies and related proteins. The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions which is a known challenge when working with more hydrophobic hybrid particles for these studies.
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