The last of our HPLC 2009 show dailies
To begin the afternoon Robert Kennedy, Fritz Emi and Paola Dugo will present tutorials on Process Scale Batch and Continuous Chromatographic Separations, Quality by Design and Principles and Applications of Speciation Analysis.
The tutorials will then be followed by the afternoon’s sessions on Monoliths, Quality by Design and LC–MS and CE–MS by Frantisek Svek, Fritz Erni and Gerard Hopfgartner.
Nobua Tanaka discusses high efficiency monolithic silica capillary columns in the first lecture of the Monoliths sessions. Fabrice Gritti then discusses mass transfer in monolithic columns with different average pore sizes followed by a lecture by Karin Cabrera on the influence of the macro- and mesopore size on the performance of monolithic HPLC columns. Emily Hilder closes the session with a talk on improving the performance of polymer monoliths to separate small molecules.
The Quality by Design sessions begins with a keynote lecture on QbD and analytical methods for European companies by Mathias Pohl followed by a talk on the impact of the new ICH quality paradigm on the European Pharmacopoeia. Christoph Meyer gives his views on QbD for HPLC from the perspective of the pharmaceutical industry and Imre Molnar reveals his approach to QbD involving HPLC method development.
The session on LC–MS and CE–MS starts with Yehia Mechref on multiple reaction monitoring LC–MS for the monosacharride compositional analysis of glycoproteins followed by a lecture on ultrahigh-resolution MS in fast LC coupling for the analysis of complex mixtures. Pierangela Palma discusses matrix effects when using LC–MS with direct EI interface and Julian Schappler closes the session with a talk on blood doping with HBOC using CE-UV–ESI-TOF-MS.
Sustainable Green Solvents in Microextraction: A Review of Recent Advancements
March 27th 2024Conventional sample preparation can be time- and resource-consuming, and a green analytical methodology can be a game-changer for scientists, in addition to facilitating selective and sensitive separations.
Transferring Methods to Compact and Portable HPLC
February 14th 2024The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.
High-Throughput Analysis of Volatile Compounds in Air, Water, and Soil Using SIFT-MS (Apr 2024)
March 27th 2024This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS, because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real time.