Investigation of Chiral Separation Conditions of Omeprazole by Supercritical Fluid Chromatography Method Scouting System

In the synthesis of medicinal drugs and agrichemical fields, synthetic compounds with optical activity are continuing to gain more attention. These compounds can show the same physical chemical properties, but show different biological activity.

It has been reported that using only one enantiomer of the optical isomer can enhance the medicinal effects and reduce the side effects when the biological activity varies between the enantiomers.

Our Methods Scouting System makes it simple for users to search and select the appropriate measurement conditions using various solvents and columns for both chiral and achiral separations.

Supercritical fluid chromatography (SFC) is well known for quick separations, easy solvent replacement, easy sample treatment after preparation, decreasing solvent cost over HPLC, and simple scale-up from analytical to preparative.

In this application, method scouting of omeprazole, used as acid suppressant, with three modifiers and six columns is carried out by using SFC and the Method Scouting Program, which is an optional program of ChromNAV Ver.2.

Experimental

Table I shows the degree in separation of omeprazole. As shown in the table, methanol and CHIRALPAK IC is suited to this measurement.

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