LC-MS in Bioanalytical and Biomedical Applications

Session 1790

Room 208C

8:30-11:25 a.m.

Di Jiang of the University of Connecticut will kick off this session with a talk on direct liquid chromatography–tandem mass spectrometry (LC–MS/MS) detection of guanine oxidations in a tumor suppression gene. Next, Ke Li of Missouri University of Science and Technology will discuss the characterization of antibody-drug conjugates in plasma by high resolution time of flight MS. Fangxu Sun of Georgia Tech University will then give a presentation on the analysis of secreted N-glycoproteins in human cells using click chemistry–based enrichment and MS. Zhou Ting of South China University of Technology will then discuss the quantification of inflammation-related lipids in ischemic stroke rates using background subtracting calibration curves with LC–MS/MS.

After the break, Alec C. Valenta of the University of Michigan will present on in vivo neurochemical monitoring using LC–MS, followed by a talk from Yadi Wang of the University of Texas at Arlington on a rapid, sensitive LC–MS/MS method for the quantitation of D-amino acids in mouse brain tissue. Next, Casey Burton of the Phelps County Regional Medical Center in Missouri will present an LC–MS/MS method for the simultaneous determination of 10 putative biomarkers for traumatic brain injury in urine.

Yiyang Zhou of Purdue University will close the session with a talk on improving HPLC resolution and increasing MS compatibility with a novel polymerized bonded phase on silica. The phase was designed to minimize or avoid the need for TFA while also increasing chromatographic resolution compared with conventional alkylsilane bonded phases.