LC?GC Europe is pleased to announce that following the success of the North American E-Application Note Alert, it will be producing a European E-Application Note Alert.
LC•GC Europe is pleased to announce that following the success of the North American E-Application Note Alert, it will be producing a European E-Application Note Alert.
The North American Alert provided readers with technical information about new and existing products, applications and techniques and the European version aims to bring those same qualities to the rest of the world.
The first of the quarterly application note alerts will be sent this month to industry professionals within Europe, Asia Pacific and the Middle East.
Notes will be arranged under five separate techniques; Sample Prep, HPLC, GC, Hyphenated Techniques and Miscellaneous, and will be accompanied by special Featured Applications Notes that will make it easier for the reader to find the notes that are relevant to them.
The application notes can be viewed and downloaded free of charge after filling out a short registration form.
New Study Examines PFAS in Breast Milk Using LC-MS/MS
November 5th 2024On the suggestion that per- and polyfluoroalkyl substances (PFAS) affect both lactation and the human metabolome, perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were measured in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Analyzing Bone Proteins in Forensic Laboratories Using LC−MS/MS
November 4th 2024A recent study compared different workflows for extracting, purifying, and analyzing bone proteins using liquid chromatography with tandem mass spectrometry (LC–MS/MS), including an in-StageTip protocol previously optimized for forensic applications, and two protocols using novel suspension-trap technology (S-Trap) and different lysis solutions. LCGC International discussed this work with Noemi Procopio of the School of Law and Policing and the Research Centre for Field Archaeology and Forensic Taphonomy at the University of Central Lancashire (UK), corresponding author of the paper that resulted from this study.