Liquid-Liquid Extraction of Polar Organic Compounds

A new dried spot-based technique involving untargeted liquid chromatography coupled with high-resolution mass spectrometry was testing for characterizing foodstuffs.

This article reports on new products introduced at Pittcon this year and in the preceding year related to sample preparation instruments, supplies, and accessories.

Analyzing trace compounds from complex samples often requires purification and pre-concentration, and online coupling of solid-phase extraction (SPE) with liquid chromatography (LC) helps minimize analysis time and solvent/sample use. Monoliths with large macropores are ideal for this coupling due to their low back pressure and versatility in various formats.

Michael Dong recently discussed sample preparation (SP) techniques for small-molecule drug substances and solid dosage forms.

LCGC International spoke to Adrián de la Fuente and Silvia Valverde Bastardo from the University of Valladolid, Spain, about the development of a miniaturized headspace solid-phase microextraction gas chromatography–quadrupole time-of-flight mass spectrometry (HS-SPME-GC–QTOF-MS) method for the analysis of biogenic volatile organic compounds (BVOCs) emitted by native Spanish trees.

A new study, published by a researcher from Chemical Characterization Solutions in Minnesota, explored a new approach for sample preparation for the chemical characterization of medical devices.