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MALDI imaging is a technique that allows the direct visualization of drugs and metabolites in tissue.
Visualize the distribution of drugs and metabolites in tissue without the time and expense of radiolabels or molecular tags!
MALDI imaging is a technique that allows the direct visualization of drugs and metabolites in tissue. One of the latest developments in this field is the seamless integration of MALDI imaging and virtual microscopy to provide detailed histopharmacology.
Because MALDI imaging uses mass spectrometry to detect targets, the distribution of each unique molecular formula can be monitored separately. The power of MALDI imaging combined with histology MALDI can help answer important questions such as:
|||Is the drug actually delivered to the targeted tissue?|
|||Which metabolites are associated with toxic or inflammatory side effects?|
|||Is the distribution or transformation of endogenous metabolites affected?|
See examples from real life DMPK research in this review article:
Castellino S, Groseclose MR, Wagner D (2011), MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis. 3(21):2427-41 http://www.future-science.com/doi/abs/10.4155/bio.11.232
See here a real-time demonstration of how histology and MALDI drug imaging are integrated in an easy and intuitive way: http://www.youtube.com/watch?v=eyyAIFHlrg0
Click here for more information about MALDI Imaging!